研究发现有益于肥胖患者的脂肪细胞
Published:04 Jun.2019    Source:中国生物技术发展中心

肥胖症是目前世界范围内最严重的公共卫生问题之一,其发病率日益增长。肥胖患者常伴有糖尿病、高血压、多囊卵巢综合征等代谢综合征。近期,在国际杂志Cell Reports上刊登了一篇关于脂肪细胞可能帮助肥胖患者减肥的文章,研究人员发现脂肪细胞间存在差异,可能预测出患者是否易患代谢性疾病,并首次鉴别出了能够“快速燃烧”的脂肪细胞来帮助肥胖患者减轻体重。

 

脂肪细胞祖细胞(APCs)提供再生细胞的储库以产生新的脂肪细胞,研究人员使用流式细胞荧光分选技术(FACS)分析人体白色脂肪组织并鉴定出三种APC亚型。APC亚型在分子上是不同的,但具有相似的增殖和脂肪形成能力。三种特性亚型的前体细胞后期或会转变成为脂肪细胞:第一种细胞会大量释放到血液中,可能会增加机体脂肪堆积的风险;第二种会以较高的比率燃烧能量,来预防体重是否增加;第三种细胞缓慢地完成了脂肪细胞通常应该完成的工作。与具有CD34低表达或CD34不表达的脂肪细胞祖细胞相比,具有CD34高表达的脂肪细胞表现出极高的脂质通量率,而由CD34-APC产生的脂肪细胞表现为米色样脂肪细胞特性及特有的内分泌谱。与腹部皮下和网膜脂肪组织相比,APC在臀肌中更为丰富,并且在2型糖尿病患者中不同部位APC亚型的分布也是不一样,该结果为进一步研究人类白色脂肪组织的异质性和2型糖尿病患者中脂肪细胞功能失调提供依据。

 

随后,研究人员进一步探究关闭脂肪释放细胞并开启脂肪燃烧细胞的方法,并对不同类型的细胞进行了分离,并结合基因表达谱和代谢、蛋白质组学等技术研究细胞中基因的表达状况并且评估了细胞中蛋白质的水平和代谢状况。研究者指出,特定的细胞亚型或会增加个体患代谢性疾病的风险,后期研究者还需要进行临床试验来证实这一问题。

 

不同人群体内的脂肪细胞是不一样的,通过研究人类机体中不同亚型的脂肪细胞,来预测不同人群的代谢健康状况,并可能探究出治疗代谢性疾病的新方法。

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